EPA Office and staff charged with evaluating the cancer slope factor (CSF) to estimate risk and set exposure standards for 1,4 dioxane for drinking water.

What are the assumptions being used for the model? Including the toxicity information, exposure assumptions (e.g., volumes consumed and at what concentrations), population (e.g., adult male vs. sensitive populations)

Please describe what is new about this effort to revise the cancer slope factor compared with the current assumptions in IRIS, the integrated risk information database. Please describe for the layperson what changes in assumptions or data are being used.